The Valiants will be looking to bounce back with a positive result on Saturday as local rivals Crewe Alexandra make the trip to Vale Park.
Following league defeats to Wycombe Wanderers and Chesterfield, Michael Brown is eager to add to the three points earned at Crawley Town on the opening day of the season.
Speaking in the week, the manager acknowledged the occasion and he is hopeful that his own experience of derby games can aid his team.
"When you win them they're special, but when you lose them they're not. That is what you play football for; you play to do well in games, and as a footballer, I wish I was out there on Saturday."
Having played in local derbies numerous times throughout his playing career, Brown knows just how important they can be to the supporters of both clubs.
"It's well known that these games mean a lot," he said.
"You get local lads that are in it every day, it's obvious that they want to be successful. It's a local derby, there will be a little bit of extra atmosphere in the stadium and that makes for a fantastic occasion."
With Crewe's undefeated record still intact after three games in Sky Bet League Two, Brown is aware that the Railwaymen will pose another challenge for the Valiants.
He said: "David [Artell] is progressing with a good team there. I think they have had an infrastructure at Crewe for quite a while, with regard to their academy and the way that they grow it.
"It has not really changed too much. I think they have had a steady flow of traffic whilst we might have come across a few problems of late.
"He [Artell] is doing a good job there, he has some talented footballers and it will be an interesting game for us."
The support from the fans has been excellent so far this campaign and Brown is encouraging all Valiants to continue backing their side this weekend.
He said: "They know me, it's a derby fixture and I have played in some fantastic ones which I'm quite pleased about. It's a strong rivalry between Port Vale and Crewe so it will be a great day for the supporters.
"We are all looking forward to it and the players know that we have worked on it and looked back at playing against Crewe.”
"It's a big game. Hopefully we will have some more players in the squad that we didn't have last week, then the window will close soon and we will get a steady side."