Vale will head into this midweek game as the underdogs with the bookies, with Sky Bet offering us at 16/5 to win.
Oxford are the favourites at 17/20 to pick up all three points , whilst the draw is at 13/5.
Chris Maguire is favourite to open the scoring in the game and can be backed at 4/1, with Conor McAlney at 9/2.
JJ Hooper is the favourite for Vale at 7/1 and behind him is Rigino Cicilia at 8/1.
Last time the Valiants faced Oxford, Vale came away with a share of the points in a 2-2 draw thanks to Rigino Cicilia and Ryan Taylor and the odds of a same score again are 12/1.
Also, if you expect Vale to keep a clean sheet in the game, then you can get Vale to win to nil at 7/1 or both teams not to score at 11/10.
Please remember that all odds are subject to change and for more information then please head to www.skybet.com.