Vale travel south this weekend as they face Cambridge United at the Abbey Stadium, but John Askey's men are deemed as the underdogs according to Sky Bet.
The newly appointed manager will be hoping to get off to the perfect start, but the Valiants are priced at 11/5 to secure all three points away from home.
Cambridge are favourites to win with odds of 6/5, but you can also back a draw, also at the price of 11/5.
Tom Pope fired home a brace and Ricky Miller scored a free-kick on the opening day of the season as Vale beat the U's 3-0, and for a repeat of that scoreline, Sky Bet are offering odds of 40/1.
There is also a price boost available if you believe Vale will come out on top in a game where both teams score. The odds were 11/2, but you can now get better value at 13/2.
With the 1-0 win away at Crawley Town and the recent goalless stalemate against Newport County at Rodney Parade, odds of 5/2 are on offer for the Valiants to keep a clean sheet, whilst a win to nil is further out at 9/2.
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