It has only been a few months since these two sides met, with that encounter coming in April 2017.
The U’s won the game 2-0 in League One at the Kassam stadium, courtesy of goals from Josh Ruffels and Chris Maguire.
It could have been more for Oxford as Marvin Johnson went close in the first-half with Deniz Mehmet denying the winger from 25-yards.
Vale also had their fair share of chances, as Chris Eagles and Remi Streete both going close.
Substiute, Sam Kelly, also went close in the dying seconds but an excellent save from Simon Eastwood allowed United to keep a clean sheet and come away with all three points.